Document Type
Journal Article
Publication Date
5-9-2018
Journal
Scientific Reports
Volume
8
Issue
1
DOI
10.1038/s41598-018-25719-8
Abstract
Bisphenol chemicals are commonly used in the manufacturing of polycarbonate plastics, polyvinyl chloride plastics, resins, and thermal printing applications. Humans are inadvertently exposed to bisphenols through contact with consumer products and/or medical devices. Recent reports have shown a link between bisphenol-a (BPA) exposure and adverse cardiovascular outcomes; although these studies have been limited to adult subjects and models. Since cardiac physiology differs significantly between the developing and adult heart, we aimed to assess the impact of BPA exposure on cardiac function, using a neonatal cardiomyocyte model. Neonatal rat ventricular myocytes were monitored to assess cell viability, spontaneous beating rate, beat rate variability, and calcium-handling parameters in the presence of control or bisphenol-supplemented media. A range of doses were tested to mimic environmental exposure (10
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Ramadan, M., Sherman, M., Jaimes, R., Chaluvadi, A., Swift, L., & Posnack, N. (2018). Disruption of neonatal cardiomyocyte physiology following exposure to bisphenol-a.. Scientific Reports, 8 (1). http://dx.doi.org/10.1038/s41598-018-25719-8
Peer Reviewed
1
Open Access
1
Included in
Medical Pharmacology Commons, Medical Physiology Commons, Pharmacology Commons, Physiology Commons
Comments
Reproduced with permission of Macmillan Publishers Ltd. Scientific Reports