Title

Channel gating regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) first cytosolic loop

Document Type

Journal Article

Publication Date

1-22-2016

Journal

Journal of Biological Chemistry

Volume

291

DOI

10.1074/jbc.M115.704809

Abstract

Background: Elucidating the mechanochemistry of ABC transporters is essential for understanding several human disease states. Results: We show a novel intermolecular binding step that governs CFTR channel activity. Conclusion: CFTR gating and ATP hydrolysis require a properly configured transmembrane domain interface. Significance: These findings indicate a new approach for discovering therapeutic targets within ABC proteins that modulate function.

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