Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

Authors

Gerald J. Sun, Johns Hopkins University
Yi Zhou, Johns Hopkins University
Shiori Ito, Johns Hopkins University
Michael A. Bonaguidi, Johns Hopkins University
Genevieve Stein-O'brien, Johns Hopkins University
Nicholas K. Kawasaki, Johns Hopkins University
Nikhil Modak, Johns Hopkins University
Yuan Zhu, Childrens National Health System
Guo Li Ming, Johns Hopkins University
Hongjun Song, Johns Hopkins University

Document Type

Journal Article

Publication Date

11-25-2015

Journal

Nature Neuroscience

Volume

18

Issue

12

DOI

10.1038/nn.4159

Abstract

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

APA Citation

Sun, G., Zhou, Y., Ito, S., Bonaguidi, M., Stein-O'brien, G., Kawasaki, N., Modak, N., Zhu, Y., Ming, G., & Song, H. (2015). Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nature Neuroscience, 18 (12). http://dx.doi.org/10.1038/nn.4159