Title

Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease.

Document Type

Journal Article

Publication Date

Spring 5-1-2021

Journal

American journal of physiology. Heart and circulatory physiology

Volume

320

Issue

5

DOI

10.1152/ajpheart.00870.2020

Keywords

Age Factors; Animals; Animals, Newborn; Chronic Disease; Cyanosis; Disease Models, Animal; Female; Fetal Heart; Fetal Hypoxia; Gene Expression Regulation, Developmental; Gestational Age; Heart Defects, Congenital; Heart Rate; Hypoxia; Mice; Myocardial Contraction; Myocytes, Cardiac; Organogenesis; Pregnancy; Prenatal Exposure Delayed Effects

Abstract

Compared with acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic fetal milieu to oxygen-rich postnatal environment is disrupted. We established a rodent model to replicate hypoxic myocardial conditions spanning perinatal development, and tested the hypothesis that chronic hypoxia impairs cardiac development. Pregnant mice were housed in hypoxia beginning at

Peer Reviewed

1

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