NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.

Authors

Jun-Ya Kaimori
Cheng-Chao Lin
Patricia Outeda
Miguel A Garcia-Gonzalez
Luis F Menezes
Erum A Hartung
Ao Li
Guanqing Wu
Hideaki Fujita
Yasunori Sato
Yasuni Nakanuma
Satoko Yamamoto
Naotsugu Ichimaru
Shiro Takahara
Yoshitaka Isaka
Terry Watnick
Luiz F Onuchic
Lisa M Guay-Woodford, George Washington University
Gregory G Germino

Document Type

Journal Article

Publication Date

8-10-2017

Journal

Scientific Reports

Volume

7

Issue

1

DOI

10.1038/s41598-017-08284-4

Keywords

Animals; Biomarkers; Cell Line; Disease Models, Animal; Enzyme Activation; Gene Expression; Humans; Intracellular Space; Male; Mice; Mice, Knockout; Mice, Transgenic; Models, Biological; Mutation; Nedd4 Ubiquitin Protein Ligases; Polycystic Kidney, Autosomal Recessive; Protein Transport; Rats; Receptors, Cell Surface; Signal Transduction; rho GTP-Binding Proteins

APA Citation

Kaimori, J., Lin, C., Outeda, P., Garcia-Gonzalez, M., Menezes, L., Hartung, E., Li, A., Wu, G., Fujita, H., Sato, Y., Nakanuma, Y., Yamamoto, S., Ichimaru, N., Takahara, S., Isaka, Y., Watnick, T., Onuchic, L., Guay-Woodford, L., & Germino, G. (2017). NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.. Scientific Reports, 7 (1). http://dx.doi.org/10.1038/s41598-017-08284-4

Peer Reviewed

1