Title

Greater Colo-Rectal Activation Phenotype in Exercised mdx Mice.

Document Type

Journal Article

Publication Date

5-2-2018

Journal

PLoS Currents

Volume

10

DOI

10.1371/currents.md.230ed3d6559b171e10279fc16e9ebef3

Abstract

Introduction: Duchenne Muscular Dystrophy is a genetic disease that is caused by a deficiency of dystrophin protein. Both Duchenne Muscular Dystrophy patients and dystrophic mice suffer from intestinal dysfunction.

Methods: The present study arose from a chance observation of differences in fecal output of dystrophic vs. normal mice during 20-minutes of forced continuous treadmill exercise. Here, we report on the effects of exercise on fecal output in two different dystrophic mutants and their normal background control strains. All fecal materials evacuated during exercise were counted, dried and weighed.

Results: Mice of both mutant dystrophic strains produced significantly more fecal material during the exercise bout than the relevant control strains.

iscussion: We propose that exercise--induced Colo--Rectal Activation Phenotype test could be used as a simple, highly sensitive, non-invasive biomarker to determine efficacy of dystrophin replacement therapies.

Comments

This is an open access PubMed Central article.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

Peer Reviewed

1

Open Access

1

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