Document Type
Journal Article
Publication Date
1-1-2015
Journal
PLoS One
Volume
10
Issue
8
Inclusive Pages
e0135678
DOI
10.1371/journal.pone.0135678
Abstract
We have previously mapped the interval on Chromosome 4 for a major polycystic kidney disease modifier (Mpkd) of the B6(Cg)-Cys1cpk/J mouse model of recessive polycystic kidney disease (PKD). Informatic analyses predicted that this interval contains at least three individual renal cystic disease severity-modulating loci (Mpkd1-3). In the current study, we provide further validation of these predicted effects using a congenic mouse line carrying the entire CAST/EiJ (CAST)-derived Mpkd1-3 interval on the C57BL/6J background. We have also generated a derivative congenic line with a refined CAST-derived Mpkd1-2 interval and demonstrated its dominantly-acting disease-modulating effects (e.g., 4.2-fold increase in total cyst area; p
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
APA Citation
Mrug, M., Zhou, J., Yang, C., Aronow, B. J., Cui, X., Schoeb, T. R., … Guay-Woodford, L. M. (2015). Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse. PLoS ONE, 10(8), e0135678. http://doi.org/10.1371/journal.pone.0135678
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of PLoS ONE.