Histopathology of graft-vs-host disease of gastrointestinal tract and liver: An update

Document Type

Journal Article

Publication Date

5-1-2016

Journal

American Journal of Clinical Pathology

Volume

145

Issue

5

DOI

10.1093/AJCP/AQW050

Keywords

Gastrointestinal pathology; Graft-vs-host disease; GVHD; Liver pathology

Abstract

© American Society for Clinical Pathology, 2016. All rights reserved. Objectives: Graft-vs-host disease (GVHD) is a donor T-cellmediated disorder affecting the recipient's skin, gastrointestinal tract, lungs, and liver. It complicates up to 70% of hematopoietic cell transplantation and is associated with high morbidity and mortality rates. Methods: An extensive review of the literature has been performed to include the most current consensus on the histopathologic diagnosis of gastrointestinal and liver GVHD. Results: In this review, we present an overview of GVHD, with emphasis on the histopathologic evaluation of gastrointestinal and liver specimens, including the most important differential diagnoses and possible pitfalls. Conclusions: Histopathologic examination remains the mainstay of diagnosis of gastrointestinal and liver GVHD and is interpreted in conjunction with clinical and laboratory data.

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