Histopathology of graft-vs-host disease of gastrointestinal tract and liver: An update
American Journal of Clinical Pathology
Gastrointestinal pathology; Graft-vs-host disease; GVHD; Liver pathology
© American Society for Clinical Pathology, 2016. All rights reserved. Objectives: Graft-vs-host disease (GVHD) is a donor T-cellmediated disorder affecting the recipient's skin, gastrointestinal tract, lungs, and liver. It complicates up to 70% of hematopoietic cell transplantation and is associated with high morbidity and mortality rates. Methods: An extensive review of the literature has been performed to include the most current consensus on the histopathologic diagnosis of gastrointestinal and liver GVHD. Results: In this review, we present an overview of GVHD, with emphasis on the histopathologic evaluation of gastrointestinal and liver specimens, including the most important differential diagnoses and possible pitfalls. Conclusions: Histopathologic examination remains the mainstay of diagnosis of gastrointestinal and liver GVHD and is interpreted in conjunction with clinical and laboratory data.
Salomao, M., Dorritie, K., Mapara, M., & Sepulveda, A. (2016). Histopathology of graft-vs-host disease of gastrointestinal tract and liver: An update. American Journal of Clinical Pathology, 145 (5). http://dx.doi.org/10.1093/AJCP/AQW050