"The sensitivity of opioid receptor types to regulation by sodium and G" by Linda L. Werling, Stephen Brown et al.
 

The sensitivity of opioid receptor types to regulation by sodium and GTP

Document Type

Journal Article

Publication Date

1-1-1984

Journal

Neuropeptides

Volume

5

Issue

1-3

DOI

10.1016/0143-4179(84)90046-5

Abstract

The effects of Na+ and GTP on agonist binding to μ, δ, and κ opioid binding sites in membranes from guinea pig cortex have been studied. All incubations were in a modified Krebs-Hepes buffer at 37°; effects of Na+ were evaluated by replacement with an equal concentration of K+. μ binding sites appeared more sensitive than δ sites, while κ sites were the least sensitive to both regulators. However, even at κ sites, Na+ induced a significant reduction in agonist affinity and GTP caused a significant reduction in maximum binding. © 1984.

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