Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex
European Journal of Pharmacology
Antimuscarinic agents; Brain; Methoctramine; Muscarinic receptor subtypes; Muscarinic receptors; Phosphoinositide hydrolysis
The cardioselective muscarinic antagonist methoctramine antagonized carbamylcholine-mediated phosphoinositide (PI) hydrolysis in a concentration-dependent fashion in dissociated rat cerebrocortical cells. However, as the concentration of methoctramine was increased above 5 μM, there was a reversal of the antagonism of the PI response. In the absence of carbamylcholine, methoctramine by itself significantly increased PI hydrolysis with a maximal effect at 30 μM. Various classes of receptor antagonists, including atropine, and ion-channel blockers were unable to block methoctramine-stimulated PI hydrolysis. © 1989.
Lee, N., Forray, C., & El-Fakahany, E. (1989). Methoctramine, a cardioselective muscarinic antagonist, stimulates phosphoinositide hydrolysis in rat cerebral cortex. European Journal of Pharmacology, 167 (2). http://dx.doi.org/10.1016/0014-2999(89)90591-8