Title

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray

Document Type

Journal Article

Publication Date

8-1-2006

Journal

Clinical and Laboratory Haematology

Volume

28

Issue

4

DOI

10.1111/j.1365-2257.2006.00803.x

Keywords

Acute myelogenous leukaemia; cDNA microarray; Granulocytic sarcoma; Nasal lesion

Abstract

This is a case report of granulocytic sarcoma occurring as a nasal lesion prior to the onset of acute myelogenous leukaemia (AML). To understand this case in more detail, we used 40 000 human cDNA microarray to identify the gene expression patterns of nonleukaemic stage bone marrow (BM), AML stage BM and AML stage peripheral blood cells and subsequently define the molecular basis of this disease progression. Of significance, we have tracked the expression profile of BM samples during the course of nonleukaemic to leukaemic progression, and identified a number of genes that may account for the growth potential of leukaemia cells and indicate poor prognosis of this case. © 2006 The Authors.

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