Genome sequence of Aedes aegypti, a major arbovirus vector


Vishvanath Nene, J. Craig Venter Institute
Jennifer R. Wortman, J. Craig Venter Institute
Daniel Lawson, European Bioinformatics Institute
Brian Haas, J. Craig Venter Institute
Chinnappa Kodira, Broad Institute
Zhijian Tu, Virginia Polytechnic Institute and State University
Brendan Loftus, J. Craig Venter Institute
Zhiyong Xi, Johns Hopkins Bloomberg School of Public Health
Karyn Megy, European Bioinformatics Institute
Manfred Grabherr, Broad Institute
Quinghu Ren, J. Craig Venter Institute
Evgeny M. Zdobnov, Université de Genève Faculté de Médecine
Neil F. Lobo, University of Notre Dame
Kathryn S. Campbell, Harvard University
Susan E. Brown, Colorado State University
Maria F. Bonaldo, Northwestern University
Jingsong Zhu, University of California, Riverside
Steven P. Sinkins, University of Oxford
David G. Hogenkamp, Purdue University
Paolo Amedeo, J. Craig Venter Institute
Peter Arensburger, University of California, Riverside
Peter W. Atkinson, University of California, Riverside
Shelby Bidwell, J. Craig Venter Institute
Jim Biedler, Virginia Polytechnic Institute and State University
Ewan Birney, European Bioinformatics Institute
Robert V. Bruggner, University of Notre Dame
Javier Costas, Fundación Pública Galega de Medicina Xenómica
Monique R. Coy, Virginia Polytechnic Institute and State University
Jonathan Crabtree, J. Craig Venter Institute
Matt Crawford, Broad Institute
Becky DeBruyn, University of Notre Dame
David DeCaprio, Broad Institute
Karin Eiglmeier, Institut Pasteur, Paris

Document Type

Journal Article

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We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of ∼4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of ∼2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.

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