Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics


Peter Arensburger, University of California, Riverside
Karine Megy, European Bioinformatics Institute
Robert M. Waterhouse, Université de Genève Faculté de Médecine
Jenica Abrudan, University of Notre Dame
Paolo Amedeo, J. Craig Venter Institute
Beatriz Antelo, Complejo Hospitalario Universitario de Santiago
Lyric Bartholomay, Iowa State University
Shelby Bidwell, Universitat Pompeu Fabra Barcelona
Elisabet Caler, J. Craig Venter Institute
Francisco Camara, Universitat Pompeu Fabra Barcelona
Corey L. Campbell, Colorado State University
Kathryn S. Campbell, Harvard University
Claudio Casola, Indiana University Bloomington
Marta T. Castro, Hospital Duran i Reynals
Ishwar Chandramouliswaran, J. Craig Venter Institute
Sinéad B. Chapman, Broad Institute
Scott Christley, University of Notre Dame
Javier Costas, Fundación Pública Galega de Medicina Xenómica
Eric Eisenstadt, J. Craig Venter Institute
Cedric Feschotte, The University of Texas at Arlington
Claire Fraser-Liggett, University of Maryland School of Medicine
Roderic Guigo, Universitat Pompeu Fabra Barcelona
Brian Haas, Broad Institute
Martin Hammond, European Bioinformatics Institute
Bill S. Hansson, Max Planck Institute for Chemical Ecology
Janet Hemingway, Liverpool School of Tropical Medicine
Sharon R. Hill, Sveriges lantbruksuniversitet
Clint Howarth, Broad Institute
Rickard Ignell, Sveriges lantbruksuniversitet
Ryan C. Kennedy, University of Notre Dame
Chinnappa D. Kodira, Roche Group
Neil F. Lobo, University of Notre Dame
Chunhong Mao, Virginia Polytechnic Institute and State University

Document Type

Journal Article

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Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout tropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.

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