Title

Munc18 plays an important role in the regulation of glutamate release during female puberty onset

Document Type

Journal Article

Publication Date

8-31-2006

Journal

Molecules and Cells

Volume

22

Issue

1

Keywords

Antisense oligodeoxynucleotide; Estradiol; Pubertal development; RNase protection assays

Abstract

Munc18, a mammalian homolog of C. elegans Unc, is essential for neurotransmitter release. The aim of this study was to identify estrogen-dependent expression of Munc18-1 and its role in the regulation of glutamate release for puberty onset. Hypothalamic munc18-1 mRNA levels were significantly increased by estrogen treatment in ovariectomized, immature female rats. During pubertal development, the munc18-1 mRNA levels dramatically increased between the juvenile period and the anestrous phase of puberty. Intracerebroventricular administration of an antisense oligodeoxynucleotide against munc18-1 mRNA significantly decreased glutamate release and delayed the day of puberty onset. These results suggest that Munc18-1, expressed in an estrogen-dependent manner, plays an important role in the onset of female puberty via the regulation of glutamate release. ©KSMCB 2006.

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