Title

The Role of Hepatocytes and Sinusoidal Cells in the Pathogenesis of Viral Hepatitis

Document Type

Journal Article

Publication Date

1-1-1988

Journal

International Review of Cytology

Volume

112

Issue

C

DOI

10.1016/S0074-7696(08)62009-4

Abstract

This chapter provides an overview of the literature concentrating on the early interactions of viruses with sinusoidal and parenchymal cells of the liver in the acute phase of hepatitis. The complex interplay of factors operative in the pathogenesis of viral hepatitis is organized into two categories of viral-host responses. The first viral-host response involves the ability of the virus to adsorb, infect, and replicate in the host tissues with which it comes in contact, dependent on its route of inoculation. In the case of hepatitis, these cells always include hepatocytes, endothelial cells, and lymphoreticular cells that reside in liver, circulation, and extrahepatic lymphoid tissue. The second interaction involves the ability of the host to impede, contain, and finally free itself of the infecting virus. The chapter describes viral-host responses that involve liver-derived cells directly. Many of the viral-host responses may effectively occur before the virus ever arrives at the liver. The lymphoreticular cells in lymph nodes and circulation have important interactions with the virus before it enters liver tissue. © 1988, Academic Press Inc.

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