Survival after induction chemotherapy and surgical resection for high-grade soft tissue sarcoma. Is radiation necessary?
Annals of Surgical Oncology
Induction chemotherapy; Soft tissue sarcoma; Surgical Resection; Survival rates; Treatment
Background: Induction chemotherapy can produce dramatic necrosis in sarcomas - raising the question of whether or not radiation is necessary. This study reviews the clinical outcome of a subset of patients with high-grade extremity soft tissue sarcomas (STS) who were treated with induction chemotherapy and surgical resection bur without radiation. Methods: Nonmetastatic, large, high-grade STS of the pelvis and extremities were treated with intra-arterial cisplatin, adriamycin, and, after 1995, ifosfamide. After induction, oncologic resection and histologic evaluation were performed. Good responders with good surgical margins were not treated with radiation. Results: Thirty-three patients, with a median follow-up of 5 years, were included. Limb salvage rate was 94%. Median tumor necrosis was 95%. Four patients developed metastatic disease with three subsequent deaths. Two local recurrences occurred; both patients were salvaged with reresection and adjuvant external beam radiotherapy, although one died of metastatic disease 10 years later. Relapse-free and overall survival is 80% and 88% at 5 and 10 years by Kaplan-Meier analysis. Conclusions: Intensive induction chemotherapy can be extremely effective for high-grade STS, permitting limb-sparing surgery in lieu of amputation. Radiation may not be necessary if a good response to induction chemotherapy and negative wide margins are achieved. All patients with large, deep, high-grade STS of the extremities should be considered candidates for induction chemotherapy.
Henshaw, R., Priebat, D., Perry, D., Shmookler, B., & Malawer, M. (2001). Survival after induction chemotherapy and surgical resection for high-grade soft tissue sarcoma. Is radiation necessary?. Annals of Surgical Oncology, 8 (6). http://dx.doi.org/10.1245/aso.2001.8.6.484