Title

Hypocalcemia in a patient with osteosarcoma and 22q11.2 deletion syndrome

Document Type

Journal Article

Publication Date

8-1-2008

Journal

Journal of Pediatric Hematology/Oncology

Volume

30

Issue

8

DOI

10.1097/MPH.0b013e318168f072

Keywords

22q11.2 deletion syndrome; Hypocalcemia; Osteosarcoma

Abstract

Hypocalcemia is a rare complication of osteosarcoma, having been described in only 4 reports. We present the case of a 16-year-old male with metastatic osteosarcoma of the right humerus who was found to have severe asymptomatic hypocalcemia. Cytogenetic analysis of peripheral blood revealed a microdeletion in band 22q11.2. Following amputation of the tumor-bearing extremity, the patient's calcium levels increased, but did not normalize. These findings suggested that the etiology of his hypocalcemia was osteoblastic utilization of calcium by the tumor, exacerbated by 22q11.2 deletion syndrome. © 2008 by Lippincott Williams & Wilkins.

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