Preoperative estimated glomerular filtration rate is a marker for postoperative complications following aseptic revision total hip arthroplasty

Document Type

Journal Article

Publication Date



European Journal of Orthopaedic Surgery and Traumatology




Glomerular filtration rate; Hip arthroplasty; Patient optimization; Postoperative complications; Revision total hip


© 2020, Springer-Verlag France SAS, part of Springer Nature. Introduction: Revision total hip arthroplasty (rTHA) is increasingly performed but may carry a high rate of complication. This aim of the study was to determine if a decreased eGFR increases risks of postoperative complications following rTHA. Methods: A retrospective cohort study using the American College of Surgeons National Quality Improvement Program Database was conducted. Patients undergoing rTHA between 2007 and 2014 were identified and stratified by glomerular filtration rates (eGFR): eGFR > 125 mL/min, eGFR 90–125 mL/min, eGFR 60–90 mL/min, eGFR 30–60 mL/min, and eGFR < 30 mL/min. The incidence of postoperative adverse events within 30 days, including cardiac, pulmonary, renal, septic, thromboembolic, urinary tract, and wound complications, blood transfusion, death, length of stay > 7 days, and unplanned return to the operating room, was assessed. The complication rates following rTHA were assessed with univariate and multivariate analysis with a significance set at p < 0.05. Results: In total, 8898 revision THA procedures were included for analysis. 28.4% of patients that underwent rTHA developed a complication following surgery. Following adjustment, an eGFR of less than 30 mL/min independently increased the odds of any complication (OR 1.447; 95% C.I. 1.010–2.074; p = 0.044), cardiac complications (OR 3.344; 95% C.I. 1.040–10.752; p = 0.043), blood transfusion (O.R. 1.623; 95% C.I. 1.122–2.352; p = 0.010), and extended length of stay (O.R. 2.392; 95% C.I. 1.526–3.759; p < 0.001) when compared to normal renal function. Conclusions: Diminished eGFR of less than 30 mL/min increased the odds of total complications, cardiac complications, blood transfusions, and extended length of stay compared to normal renal function.

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