Title

Orbital augmentation by hydroxylapatite-based composites

Document Type

Journal Article

Publication Date

1-1-1991

Journal

Ophthalmic Plastic and Reconstructive Surgery

Volume

7

Issue

1

DOI

10.1097/00002341-199103000-00002

Keywords

Avitene; Calcium sulfate; Ceramics; Computed tomography; Enophthalmos; Hydroxylapatite; Implantable biomaterials; Orbit; Orbital defects; Orbital volume

Abstract

Hydroxylapatite, a synthetic bone mineral, was implanted alone or as a composite with either calcium sulfate (plaster of Paris) or Avitene (microfibrillar collagen hemostatic agent) into the orbital bony defects and orbital soft tissues of 23 rabbits. Plain Avitene was also placed into these bony and soft tissue sites and bone defects with no additives served as controls. Additionally, each implant material was placed into subcutaneous tissues to determine its relative inflammatory potential. New bone formation was noted in bony defects as early as 10 days. Bone ingrowth was greatest when hydroxylapatite was in direct apposition to bone. Material implanted away from bone showed predominately connective tissue ingrowth. Minimal inflammatory reaction was noted early on in the hydroxylapatite and hydroxylapa-tite/calcium sulfate samples and had resolved by 2 months when placed in both soft and bony tissues. Samples of Avitene and the hydroxylapatite/Avitene composite demonstrated an intense inflammatory response, and in several cases large granulomas were seen after 2 months. © 1991 Raven Press, Ltd., New York.

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