Title

Incidence and Early Course of Retlnonathy of Prematurity

Authors

Earl A. Palmer, Oregon Health & Science University
John T. Flynn, Bascom Palmer Eye Institute
Robert J. Hardy, University of Texas System
Dale L. Phelps, SUNY Upstate Medical University
Cynthia L. Phillips, Oregon Health & Science University
David B. Schaffer, The Children's Hospital of Philadelphia
Betty Tung, University of Texas System
Frederick J. Elsas
Jan M. Botsford, University of Alabama Hospital at Birmingham
Karen W. Braune, University of Alabama Hospital at Birmingham
George Cassady, University of Alabama Hospital at Birmingham
John A. Jones, University of Alabama Hospital at Birmingham
James A. Kimble, University of Alabama Hospital at Birmingham
Lanning Kline, University of Alabama Hospital at Birmingham
Douglas Witherspoon, University of Alabama Hospital at Birmingham
Malinda Young, University of Alabama Hospital at Birmingham
Alan M. Roth, UC Davis Medical Center
Byron H. Demorest, UC Davis Medical Center
Roberta Erickson, UC Davis Medical Center
William S. Gilbert, Georgetown University Medical Center
Georgia A. Chrousos, Georgetown University Medical Center
David S. Friendly, Georgetown University Medical Center
Mohammad Jaafar, Georgetown University Medical Center
Marshall P. Keys, Georgetown University Medical Center
Martin P. Kolsky, Georgetown University Medical Center
Patricia Ann Mercer, Georgetown University Medical Center
Donna O'Neill, Georgetown University Medical Center
John F. O'Neill, Georgetown University Medical Center
Edward S. Parelhoff, Georgetown University Medical Center
Ed Perraut, Georgetown University Medical Center
A. Raymond Pilkerton, Georgetown University Medical Center
David Plotsky, Georgetown University Medical Center
John Clarkson, Jackson Memorial Hospital

Document Type

Journal Article

Publication Date

1-1-1991

Journal

Ophthalmology

Volume

98

Issue

11

DOI

10.1016/S0161-6420(91)32074-8

Abstract

In the Multicenter Trial of Cryotherapy for Retinopathy of Prematurity (ROP), 4099 infants weighing less than 1251 g at birth underwent sequential ophthalmic examinations, beginning at age 4 to 6 weeks, to monitor the incidence and course of ROP. Overall, 65.8% of the infants developed ROP to some degree; 81.6% for infants of less than 1000 g birth weight. As expected, ROP incidence and severity were higher in lower birth weight and gestational age categories. Black infants appeared less susceptible to ROP, of all severity categories, than nonblack infants. The timing of retinal vascular events correlated more closely with postconceptional age than with postnatal age, implicating the level of maturity more than postnatal environmental influences in governing the timing of these vascular events. These results include the current incidence of various severity stages of ROP found in the United States and provide new. insight into the development of ROP. © 1991, American Academy of Ophthalmology, Inc. All rights reserved.

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