Title

Ocular Disease

Document Type

Journal Article

Publication Date

12-1-2013

Journal

The Autoimmune Diseases: Fifth Edition

DOI

10.1016/B978-0-12-384929-8.00055-1

Keywords

Antigen; Cytokines; Experimental animal uveitis (EAU); Human leukocyte antigen (HLA); Inflammation; Tumor necrosis factor-alpha (TNFα); Uveitis

Abstract

Uveitis consists of inflammation of the iris, ciliary body, and choroid. Anatomical location, type of inflammation, and demographic features are important factors for elucidating the underlying etiology. The presence of uveitogenic antigens in the human eye have been established, and are thought to incite disease in conjunction with disarray of the immune system. Several elements including genetics, hormones, and environmental influences are thought to play a role in the development of uveitis. Experimental autoimmune uveitis (EAU) has been important for studying the molecular mechanisms involved, including the role of cellular immunity and cytokines. While many treatment options for uveitis exist, the continued understanding of the disease process allows for more tailored therapies. © 2014 Elsevier Inc. All rights reserved.

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