In vitro fertilization in women under 35: Counseling should differ by age

Document Type

Journal Article

Publication Date



Journal of Assisted Reproduction and Genetics








Cumulative live birth rate; In vitro fertilization; IVF; Young women


© Springer Science+Business Media New York 2015. Purpose The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years. Methods A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single centerwas conducted. A competing-risk regression model was used to estimate the cumulative probability and 95% confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric. Results Among 7243 women who underwent 16,792 cycles, there were 163 (2.3%) women <25 years, 1691 (23.3%) women 25 to <30 years, and 5389 (74.4%) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed bywomen 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rateswere 58%(95%CI 0.51–0.66) amongwomen <25 years, 69% (95%CI 0.67–0.71) among women 25 to <30 years, and 64% (95% CI 0.63–0.65) among women 30 to <35 years. Conclusions Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.