Is younger better? Donor age less than 25 does not predict more favorable outcomes after in vitro fertilization.

Leigh A Humphries
Laura E Dodge
Erin B Kennedy
Kathryn C Humm, George Washington University
Michele R Hacker
Denny Sakkas

Epub ahead of print


OBJECTIVE: To determine whether younger oocyte donor age is associated with better outcomes after in vitro fertilization (IVF) compared with older oocyte donor age.

DESIGN: A retrospective cohort study.

SETTING: Large academically affiliated infertility treatment center.

PATIENTS: We included all women ≥ 18 years who started their first fresh cycle using donor oocytes at our center from January 2002 through October 2017; only the first oocyte recipient cycle was analyzed.

INTERVENTION: Log-binomial regression was used to compare the incidence of clinical pregnancy and live birth among the following donor age groups: < 25 years, 25 to < 30 years, and 30 to

MAIN OUTCOME MEASURE: Incidence of clinical pregnancy and live birth among donor age groups.

RESULTS: We included 774 donor cycles; 269 (34.8%) used donors < 25 years, 399 (51.6%) used donors 25 to < 30 years, and 106 (13.7%) used donors 30 to < 35 years. Median donor age was 26 years (range 18-34.5), and median recipient age and partner age were both 42 years. Per cycle start, after adjusting for recipient age, cycles using donors < 25 years were not associated with a higher incidence of clinical pregnancy (RR 0.90; 95% CI 0.77-1.06) or live birth (RR 0.87; 95% CI 0.72-1.04) compared with donors age 25-< 30 years.

CONCLUSIONS: Donor age < 25 was not associated with better outcomes after IVF. Under the age of 30, the prioritization of