Biomed Res Int
CD8-Positive T-Lymphocytes--immunology; HIV Infections--complications; HIV Infections--immunology; Myocardial Infarction--complications; Myocardial Infarction--immunology
Human Immunodeficiency Virus- (HIV-) infected persons have a higher risk for acute myocardial infarction (AMI) than HIV-uninfected persons. Earlier studies suggest that HIV viral load, CD4+ T-cell count, and antiretroviral therapy are associated with cardiovascular disease (CVD) risk. Whether CD8+ T-cell count is associated with CVD risk is not clear. We investigated the association between CD8+ T-cell count and incident AMI in a cohort of 73,398 people (of which 97.3% were men) enrolled in the U.S. Veterans Aging Cohort Study-Virtual Cohort (VACS-VC). Compared to uninfected people, HIV-infected people with high baseline CD8+ T-cell counts (>1065 cells/mm3) had increased AMI risk (adjusted HR=1.82, P
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Oluwatosin A. Badejo, Chung-Chou Chang, Kaku A. So-Armah, et al. (2015) CD8+ T-Cells Count in Acute Myocardial Infarction in HIV Disease in a Predominantly Male Cohort. BioMed Research International, vol. 2015, Article ID 246870, 5 pages, 2015. doi:10.1155/2015/246870.