Reduced acetylation of procainamide by para-aminobenzoic acid
Journal of the American College of Cardiology
Acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide. Coadministration of para-aminobenzoic acid was observed to decrease the biotransformation of procainamide to N-acetylprocainamide in a patient with rapid acetylation kinetics. In view of the distinct antiarrhythmic and toxic properties of procainamide and N-acetylprocainamide,the observed drug interference may have great clinical relevance in long-term oral antiarrhythmic therapy and in instances where other drugs converge for acetylation. © 1986, American College of Cardiology Foundation. All rights reserved.
Nylen, E., Cohen, A., Wish, M., Lima, J., & Finkelstein, J. (1986). Reduced acetylation of procainamide by para-aminobenzoic acid. Journal of the American College of Cardiology, 7 (1). http://dx.doi.org/10.1016/S0735-1097(86)80280-7