Title

Reduced acetylation of procainamide by para-aminobenzoic acid

Document Type

Journal Article

Publication Date

1-1-1986

Journal

Journal of the American College of Cardiology

Volume

7

Issue

1

DOI

10.1016/S0735-1097(86)80280-7

Abstract

Acetylation is the major route of metabolism of many drugs including the antiarrhythmic agent procainamide. Coadministration of para-aminobenzoic acid was observed to decrease the biotransformation of procainamide to N-acetylprocainamide in a patient with rapid acetylation kinetics. In view of the distinct antiarrhythmic and toxic properties of procainamide and N-acetylprocainamide,the observed drug interference may have great clinical relevance in long-term oral antiarrhythmic therapy and in instances where other drugs converge for acetylation. © 1986, American College of Cardiology Foundation. All rights reserved.

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