Evidence for cigarette smoke-induced calcitonin secretion from lungs of man and hamster
Document Type
Journal Article
Publication Date
1-1-1988
Journal
Life Sciences
Volume
42
Issue
23
DOI
10.1016/0024-3205(88)90185-3
Abstract
In hamsters, acute cigarette smoke inhalation increased serum levels of the hormone calcitonin; and, in humans, smoking of two high-nicotine content cigarettes increased serum and urine levels of this hormone. The source of this immunoreactive calcitonin (iCT) does not appear to be the thyroid gland, since previously thyroidectomized patients demonstrated a similar response. In the hamster, the increased serum iCT levels were accompanied by a decreased lung tissue iCT content and hypocalcemia. It is suggested that the source of the cigarette smoke-induced hypercalcitonemia is the lung, possibly from the iCT-containing pulmonary neuroendocrine (PNE) cells. Moreover, this response appears to be dependent on the nicotine content of the cigarettes. © 1988.
APA Citation
Tabassian, A., Nylen, E., Giron, A., Snider, R., Cassidy, M., & Becker, K. (1988). Evidence for cigarette smoke-induced calcitonin secretion from lungs of man and hamster. Life Sciences, 42 (23). http://dx.doi.org/10.1016/0024-3205(88)90185-3