Title

Pathobiology of Lung Tumors Induced in Hamsters by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and the Modulating Effect of Hyperoxia

Document Type

Journal Article

Publication Date

3-15-1990

Journal

Cancer Research

Volume

50

Issue

6

Abstract

Neuroendocrine lung cancer is among the most common types of lung cancers in smokers. We have recently shown that exposure of hamsters to N-nitrosodiethylamine and hyperoxia causes a high incidence of this tumor type. In this study, we show that the tobacco-specific nitrosamine 4-(meth-ylnitrosamino)-l-(3-pyridyl)-l-butanone also causes neuroendocrine lung tumors in hyperoxic hamsters. Animals maintained in ambient air while being treated with 4-(methytaitrosammo)-l-(3-pyridyl)-l-butanone developed pulmonary adenomas composed of Clara cells and alveolar type II cells. Pathogenesis experiments provide evidence for the tumors caused by 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone in ambient air being derived from Clara cells. In the hyperoxic hamsters, the neuroendocrine carcinogenesis appears to involve two stages: (a) transformation of focal alveolar type II cells into neuroendocrine cells and (b) development of neuroendocrine lung tumors from such foci. © 1990, American Association for Cancer Research. All rights reserved.

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