Growth hormone deficiency in adults: A review

Document Type

Journal Article

Publication Date

1-1-1996

Journal

American Journal of the Medical Sciences

Volume

311

Issue

4

DOI

10.1097/00000441-199604000-00001

Keywords

Growth hormone deficiency; Hormone therapy

Abstract

For more than 35 years, growth hormone (GH) has been used to promote linear growth in GH-deficient children. Previously, GH replacement in adults was limited to the supply of human pituitary-derived GH. In addition, until recently, GH replacement was not deemed clinically indicated. With the introduction of recombinant human prion-free GH, replacement therapy in GH- deficient adults has become feasible, and its use has burgeoned. In this review, recent studies on GH therapy in healthy and GH-deficient adults are evaluated to provide a rational basis for the widened scope of its clinical application.

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