Growth hormone deficiency in adults: A review
American Journal of the Medical Sciences
Growth hormone deficiency; Hormone therapy
For more than 35 years, growth hormone (GH) has been used to promote linear growth in GH-deficient children. Previously, GH replacement in adults was limited to the supply of human pituitary-derived GH. In addition, until recently, GH replacement was not deemed clinically indicated. With the introduction of recombinant human prion-free GH, replacement therapy in GH- deficient adults has become feasible, and its use has burgeoned. In this review, recent studies on GH therapy in healthy and GH-deficient adults are evaluated to provide a rational basis for the widened scope of its clinical application.
Meling, T., & Nylen, E. (1996). Growth hormone deficiency in adults: A review. American Journal of the Medical Sciences, 311 (4). http://dx.doi.org/10.1097/00000441-199604000-00001