Title

Potential Impact on Clinical Decision Making via a Genome-Wide Expression Profiling: A Case Report

Document Type

Journal Article

Publication Date

11-1-2016

Journal

Urology Case Reports

Volume

9

DOI

10.1016/j.eucr.2016.08.010

Keywords

Genomics; Neuroendocrine; Prostate

Abstract

© 2016 Management of men with prostate cancer is fraught with uncertainty as physicians and patients balance efficacy with potential toxicity and diminished quality of life. Utilization of genomics as a prognostic biomarker has improved the informed decision-making process by enabling more rationale treatment choices. Recently investigations have begun to determine whether genomic information from tumor transcriptome data can be used to impact clinical decision-making beyond prognosis. Here we discuss the potential of genomics to alter management of a patient who presented with high-risk prostate adenocarcinoma. We suggest that this information help selecting patients for advanced imaging, chemotherapies, or clinical trial.

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