Title

Inflammation associates with impaired small arterial elasticity early in HIV disease

Document Type

Journal Article

Publication Date

6-1-2018

Journal

Open Forum Infectious Diseases

Volume

5

Issue

6

DOI

10.1093/ofid/ofy117

Keywords

Arterial elasticity; Cardiovascular disease; HIV infection; Systemic inflammation; Vascular dysfunction

Abstract

© The Author(s) 2018. We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

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