Inflammation associates with impaired small arterial elasticity early in HIV disease

Authors

Tess E. Peterson, Hennepin County Medical Center
Katherine Huppler Hullsiek, University of Minnesota Twin Cities
Nicole Wyman Engen, University of Minnesota Twin Cities
Nagalingeswaran Kumarasamy, VHS Medical Centre India
Anne Mette Lebech, Københavns Universitet
Angelike Liappis, Washington DC VA Medical Center
Antonios Papadopoulos, National and Kapodistrian University of Athens
Mark N. Polizzotto, The Kirby Institute
Pamela J. Schreiner, Hennepin County Medical Center
Daniel Duprez, University of Minnesota Twin Cities
Jason V. Baker, University of Minnesota Twin Cities

Document Type

Journal Article

Publication Date

6-1-2018

Journal

Open Forum Infectious Diseases

Volume

5

Issue

6

DOI

10.1093/ofid/ofy117

Keywords

Arterial elasticity; Cardiovascular disease; HIV infection; Systemic inflammation; Vascular dysfunction

Abstract

© The Author(s) 2018. We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

APA Citation

Peterson, T., Hullsiek, K., Engen, N., Kumarasamy, N., Lebech, A., Liappis, A., Papadopoulos, A., Polizzotto, M., Schreiner, P., Duprez, D., & Baker, J. (2018). Inflammation associates with impaired small arterial elasticity early in HIV disease. Open Forum Infectious Diseases, 5 (6). http://dx.doi.org/10.1093/ofid/ofy117