Anti-ischemic effects of Amlodipine in patients with stable angina pectoris and myocardial ischemia during daily life
American Journal of Cardiology
Ambulatory electrocardiographic monitoring was used to assess the anti- ischemic effects of amlodipine in a subset of 56 patients enrolled in a 14- week withdrawal study; amlodipine therapy resulted in a marked decrease in the overall mean number of ischemic events and the average number of transient ischemic episodes (p <0.005). Amlodipine substantially reduced the number of ischemic events among all patients during the single-blind phase, with further significant reductions recorded among patients who remained on amlodipine during double-blind therapy, but the number of ischemic events increased almost to baseline levels in patients switched to placebo during double-blind therapy (p = 0.01 by analysis of variance).
Deedwania, P., Allen, J., Bittar, N., Bouchard, A., Brandon, M., Bruns, D., Carbajal, E., Checton, J., Corder, C., Cutler, N., Thompson Dale, H., Das, G., DeAbate, A., Dittrich, H., Doherty, J., Douglas, M., Edelstein, R., Elson, A., Fogel, M., Frishman, W., Gershan, R., Glaser, A., Glasser, S., Glode, J., Gorwit, J., Goyle, K., Haidet, G., Hannis, M., Hilty, R., Holt, J., Johnson, D., & Katz, R. (1999). Anti-ischemic effects of Amlodipine in patients with stable angina pectoris and myocardial ischemia during daily life. American Journal of Cardiology, 83 (7). http://dx.doi.org/10.1016/S0002-9149(99)00024-7