Bioassay for SF 86-327, a new antifungal agent
Antimicrobial Agents and Chemotherapy
A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.
Kan, V., Henderson, D., & Bennett, J. (1986). Bioassay for SF 86-327, a new antifungal agent. Antimicrobial Agents and Chemotherapy, 30 (4). http://dx.doi.org/10.1128/AAC.30.4.628