Title

Bioassay for SF 86-327, a new antifungal agent

Document Type

Journal Article

Publication Date

1-1-1986

Journal

Antimicrobial Agents and Chemotherapy

Volume

30

Issue

4

DOI

10.1128/AAC.30.4.628

Abstract

A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.

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