Title

Macrolide and clindamycin resistance in Staphylococcus aureus isolates and antibiotic use in a veterans affairs medical center

Document Type

Journal Article

Publication Date

2-1-2008

Journal

Infection Control and Hospital Epidemiology

Volume

29

Issue

2

DOI

10.1086/526448

Abstract

Presented in part: 46th Interscience Conference on Antimicrobial Agents and Chemotherapy; San Francisco, CA; September 27-30, 2006 (Abstract C2-1140). A retrospective analysis of 13,946 Staphylococcus aureus isolates revealed a stable incidence of isolates that were resistant to both clindamycin and erythromycin, but a significantly increasing incidence of isolates that were susceptible to clindamycin and resistant to erythromycin during 1991-1995, 1996-2000, and 2001-2005. The use of macrolides and clindamycin also increased during 1996-2005. The incidence of S. aureus isolates with inducible clindamycin resistance increased steadily and significantly during the period from August 2004 through December 2005. © 2007 by The Society for Healthcare Epidemiology of America. All rights reserved.

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