Novel B cell therapeutic targets in transplantation and immune-mediated glomerular diseases

Document Type

Journal Article

Publication Date

2-8-2010

Journal

Clinical Journal of the American Society of Nephrology

Volume

5

Issue

1

DOI

10.2215/CJN.04580709

Abstract

B cells and antibodies play an important role in the alloresponse to renal grafts as well as in immune-mediated glomerular diseases. In transplantation, greater recognition and improved diagnosis of antibody-mediated rejection have been a catalyst to the introduction of newer drugs and regimens that target B cells, plasma cells, and donor-specific antibodies to improve the outcome associated with antibody-mediated rejection. In immune-mediated renal disease, novel and more selective B cell therapies are gradually modifying the traditional therapeutic approach that consists of steroids and other immunosuppressants. A new era of selective and more effective immunosuppression agents that target the humoral response is finally emerging in transplantation and renal diseases. Copyright © 2010 by the American Society of Nephrology.

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