Transmission of methicillin-resistant staphylococcus aureus infection through solid organ transplantation: Confirmation via whole genome sequencing

Document Type

Journal Article

Publication Date

1-1-2014

Journal

American Journal of Transplantation

Volume

14

Issue

11

DOI

10.1111/ajt.12898

Abstract

© Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons. We describe two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Both recipients developed recurrent MRSA infection despite appropriate antibiotic therapy, and required prolonged hospitalization and hospital readmission. Comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates confirmed donor-derived transmission. Current guidelines emphasize the risk posed by donors with bacteremia from multidrug-resistant organisms. This investigation suggests that, particularly in the setting of donor endocarditis, even a standard course of prophylactic antibiotics may not be sufficient to prevent donor-derived infection. This manuscript describes two cases of donor-derived methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, confirmed through comparison of S. aureus whole genome sequence of DNA extracted from fixed donor tissue and recipients' isolates, that developed after transplantation of organs from a common donor who died from acute MRSA endocarditis. Also see case report by Altman et al on page 2640.

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