Multiloci stereotactic transplantation of autologous adrenal medullary tissue to the putamen and caudatum in Parkinson's disease. Technical note
Stereotactic and Functional Neurosurgery
adrenal medulla; caudate nucleus; Parkinson's disease; putamen; stereotactic surgery; tissue transplantation
Adrenal to striatum transplants may be effective, but many technical issues are still debated. A procedure whereby a number of grafts were stereotactically placed at the putamen and caudatum is reported. It enables grafting deep nuclei, such as the putamen, the most denervated structure in Parkinson's disease, and allows a wide-spread spatial distribution of multiple grafts within these huge targets, conceivably enhancing the local release of neurotransmitters at the site or in the vicinity of the denervated receptors. It also enables the use of a sizeable volume of tissue, presumably a crucial but as yet unknown factor. Although preliminary, the present data seem to warrant further clinical trials.
Schvarcz, J., Devoto, M., Meiss, R., Torrieri, A., Genero, M., & Armando, I. (1990). Multiloci stereotactic transplantation of autologous adrenal medullary tissue to the putamen and caudatum in Parkinson's disease. Technical note. Stereotactic and Functional Neurosurgery, 54-55 (). http://dx.doi.org/10.1159/000100223