Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: Studies in dopamine receptor knockout mice

Document Type

Journal Article

Publication Date

2-1-2008

Journal

American Journal of Physiology - Heart and Circulatory Physiology

Volume

294

Issue

2

DOI

10.1152/ajpheart.01036.2007

Keywords

Dopamine receptor; Knockout mice

Abstract

Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone, angiotensin, catecholamines, endothelin, oxytocin, prolactin pro-opiomelancortin, reactive oxygen species, renin, and vasopressin. Dopamine receptors are classified into D 1-like (D1 and D5) and D2-like (D2, D3, and D4) subtypes based on their structure and pharmacology. In recent years, mice deficient in one or more of the five dopamine receptor subtypes have been generated, leading to a better understanding of the physiological role of each of the dopamine receptor subtypes. This review summarizes the results from studies of various dopamine receptor mutant mice on the role of individual dopamine receptor subtypes and their interactions with other G protein-coupled receptors in the regulation of blood pressure. Copyright © 2008 the American Physiological Society.

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