Title

Disturbed immunological responsiveness during Plasmodium berghei infection

Document Type

Journal Article

Publication Date

1-1-1980

Journal

Indian Journal of Medical Research

Volume

72

Issue

1

Abstract

Immunological response to a nonspecific antigen, i.e., sheep red blood cells (SRBC), in mice infected with the malarial parasite, Plasmodium berghei, was studied. The P. berghei infection caused a complete inhibition of immune response of the host to SRBC and this inhibition was well marked after first peak parasitaemia. The immunodepression caused by the parasite was found to be a temporary one, since it could be restored gradually by eradicating the infection with chloroquine therapy. It is thus felt that in addition to specific immunodepression by the parasite antigen, immunodepression towards other antigens like the SRBC is also produced. This may result in inhibition of the response in an effective way to the parasite or another strain of Plasmodium multiplying in blood.

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