Title

Acquired resistance in experimental giardiasis

Document Type

Journal Article

Publication Date

12-1-1980

Journal

Indian Journal of Medical Research

Volume

72

Issue

2

Abstract

Giardia lamblia cysts inoculated intraoesophageally could proliferate into trophozoites in the duodenum of Swiss mice and animals became infected within 4±2 days. Twenty one animals were observed up to the stage of spontaneous resolution of the infection. All the animals underwent spontaneous resolution of the infection by day 41 post-inoculation. Another batch of 15 infected animals was subjected to metronidazole therapy from the 11th day onwards, for a week, to eradicate the infection. Spontaneously cured as well as the drug-treated animals were reinfected with G. lamblia cysts. It was then observed that cysts in the stools appeared late (6±2 days), the intensity of G. lamblia infection was significantly less (P<0.05) and the animals had another spontaneous cure sooner. Five of the spontaneously cured animals were found to be completely refractory to reinfection.

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