Acquired resistance in experimental giardiasis
Indian Journal of Medical Research
Giardia lamblia cysts inoculated intraoesophageally could proliferate into trophozoites in the duodenum of Swiss mice and animals became infected within 4±2 days. Twenty one animals were observed up to the stage of spontaneous resolution of the infection. All the animals underwent spontaneous resolution of the infection by day 41 post-inoculation. Another batch of 15 infected animals was subjected to metronidazole therapy from the 11th day onwards, for a week, to eradicate the infection. Spontaneously cured as well as the drug-treated animals were reinfected with G. lamblia cysts. It was then observed that cysts in the stools appeared late (6±2 days), the intensity of G. lamblia infection was significantly less (P<0.05) and the animals had another spontaneous cure sooner. Five of the spontaneously cured animals were found to be completely refractory to reinfection.
Vinayak, V., Sharma, G., Aggarwal, A., & Naik, S. (1980). Acquired resistance in experimental giardiasis. Indian Journal of Medical Research, 72 (2). Retrieved from https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/3652