Cellular and humoral immune responses in rats experimentally infected with Plasmodium berghei

Document Type

Journal Article

Publication Date



Indian Journal of Medical Research






Wistar albino rats infected with P. berghei were sacrificed on days 7, 14, 21, and 28 postinfection i.e. during the course of infection and after the cessation of infection. The humoral as well as cell mediated immune responses against the parasite antigen was observed in these animals by IHA, CIEP, LMI tests and T and B cell counts, respectively. The agglutinins as well as the precipitins appeared on day 7, reached a peak on day 14 and started declining on day 18 PI. The LMI followed the same pattern. Both T and B cells decreased in infected animals as compared to non-infected controls. The decrease in the number of these cells was maximum on day 14. The study highlights the fact that both humoral and cellular immune responses get altered in malaria infection and tend to become normal after the cessation of infection.

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