Title

An ounce of prevention on a budget: A nonprofit approach to developing vaccines against neglected diseases

Document Type

Journal Article

Publication Date

8-11-2006

Journal

Expert Review of Vaccines

Volume

5

Issue

2

DOI

10.1586/14760584.5.2.189

Keywords

Hookworm; Necator americanus; Neglected tropical diseases; Product development; Public-private partnership; Recombinant vaccine

Abstract

This article provides a perspective on vaccine development for neglected tropical diseases in the nonprofit setting, with particular emphasis on recombinant protein vaccines. The Human Hookworm Vaccine Initiative is discussed as a model product development public-private partnership, and the major challenges are covered that accompany antigen selection, gene cloning, fermentation and purification process development, assay development, vaccine formulation and testing and clinical evaluation for those developing vaccines, especially against neglected tropical diseases, in the nonprofit sector. Throughout this perspective, special emphasis is placed on the growing promise that product development public-private partnetships hold for developing vaccines for the world's poorest people. © 2006 Future Drugs Ltd.

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