Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates
Parasitic Helminths: Targets, Screens, Drugs and Vaccines
Genomics; Immunomics; Proteomics; Schistosomiasis; Sm-TSP-2; Transcriptomics; Vaccine
Vaccine development for schistosomiasis has had a chequered history. Many antigens that showed initial promise in murine models dropped by the wayside and only two vaccines are currently in clinical trials. In this chapter, we discuss antigen discovery in light of the "schistosomics" revolution, with a particular focus on immunomics, and undertake some crystal ball gazing on where all this information might lead us in the near future. We then discuss the transition of neglected tropical disease vaccines towards clinical trials via a public-private partnership model, using the discovery and preclinical development of the Sm-TSP-2 schistosomiasis vaccine as a case study. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA.
Loukas, A., Gaze, S., Pearson, M., Doolan, D., Felgner, P., Diemert, D., Mcmanus, D., Driguez, P., & Bethony, J. (2012). Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates. Parasitic Helminths: Targets, Screens, Drugs and Vaccines, (). http://dx.doi.org/10.1002/9783527652969.ch25