Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.

Authors

Michael A Smith
Chia-Chien Chiang
Kamelia Zerrouki
Saifur Rahman
Wendy I White
Katie Streicher
William A Rees
Adam Schiffenbauer
Lisa G. Rider, George Washington University
Frederick W Miller
Zerai Manna
Sarfaraz Hasni
Mariana J Kaplan
Richard Siegel
Dominic Sinibaldi
Miguel A Sanjuan
Kerry A Casey

Document Type

Journal Article

Publication Date

3-10-2020

Journal

Sci Rep

Volume

10

Issue

1

DOI

10.1038/s41598-020-60563-9

Abstract

Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined whether measurement of circulating proteins, which enter the bloodstream from inflamed tissues, also offers insight into global IFN activity. Using a novel protocol we generated 1,132 aptamer-based protein measurements from anti-dsDNA

Comments

This is an open access PubMed Central article.

APA Citation

Smith, M., Chiang, C., Zerrouki, K., Rahman, S., White, W., Streicher, K., Rees, W., Schiffenbauer, A., Rider, L. G., Miller, F., Manna, Z., Hasni, S., Kaplan, M., Siegel, R., Sinibaldi, D., Sanjuan, M., & Casey, K. (2020). Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.. Sci Rep, 10 (1). http://dx.doi.org/10.1038/s41598-020-60563-9

Peer Reviewed

1

Open Access

1