Title

Using the circulating proteome to assess type I interferon activity in systemic lupus erythematosus.

Document Type

Journal Article

Publication Date

3-10-2020

Journal

Sci Rep

Volume

10

Issue

1

DOI

10.1038/s41598-020-60563-9

Abstract

Type I interferon (IFN) drives pathology in systemic lupus erythematosus (SLE) and can be tracked via IFN-inducible transcripts in blood. Here, we examined whether measurement of circulating proteins, which enter the bloodstream from inflamed tissues, also offers insight into global IFN activity. Using a novel protocol we generated 1,132 aptamer-based protein measurements from anti-dsDNA

Comments

This is an open access PubMed Central article.

Peer Reviewed

1

Open Access

1

Find in your library

Share

COinS