Title

Hierarchical Fabrication of Engineered Vascularized Bone Biphasic Constructs via Dual 3D Bioprinting: Integrating Regional Bioactive Factors into Architectural Design.

Document Type

Journal Article

Publication Date

9-1-2016

Journal

Advanced Healthcare Materials

Volume

5

Issue

17

DOI

10.1002/adhm.201600505

Keywords

Bone and Bones; Human Umbilical Vein Endothelial Cells; Humans; Printing, Three-Dimensional; Tissue Engineering

Abstract

A biphasic artificial vascularized bone construct with regional bioactive factors is presented using dual 3D bioprinting platform technique, thereby forming a large functional bone grafts with organized vascular networks. Biocompatible mussel-inspired chemistry and "thiol-ene" click reaction are used to regionally immobilize bioactive factors during construct fabrication for modulating or improving cellular events.

Comments

"This is an open access publication. Click on link for full-text access"

Peer Reviewed

1

Open Access

1