Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001-2016
Dermatitis : contact, atopic, occupational, drug
BACKGROUND: Ingredients in nail care products may lead to allergic and/or irritant contact dermatitis. OBJECTIVE: The aims of this study were to determine frequency of contact dermatitis associated with nail care products, characterize associated body sites, and describe causative allergens. METHODS: A retrospective analysis was conducted with the North American Contact Dermatitis Group data between 2001 and 2016. RESULTS: Of the 38,775 patients tested, 769 (2.0%) had: 1) more than 1 allergic patch test reaction associated with a nail care product (n = 746), 2) irritant contact dermatitis associated with a nail care product (n = 14), or 3) both (n = 9). Primary body sites included the face (43.0%) and hands (27.6%). The top 5 allergens were (2-hydroxyethyl methacrylate (273/482, 56.6%), methyl methacrylate (210/755, 27.8%), ethyl acrylate (190/755, 25.2%), ethyl-2-cyanoacrylate (12/175, 6.9%) and tosylamide (273/755, 36.2%). Frequency of allergy to 2-hydroxyethyl methacrylate (P = 0.0069) and ethyl acrylate (P = 0.0024) significantly increased over the study period, whereas allergy secondary to tosylamide significantly decreased (P < 0.0001). CONCLUSIONS: As long-lasting nail techniques become widespread, the prevalence of contact dermatitis to nail care products is expected to increase. Almost one-fifth of nail care product-associated allergens would have been missed without additional screening allergens beyond the North American Contact Dermatitis Group series, underscoring the need for testing to a broad array of allergens.
Warshaw, E., Voller, L., Silverberg, J., DeKoven, J., Atwater, A., Maibach, H., Reeder, M., Sasseville, D., Belsito, D., DeLeo, V., Fransway, A., Fowler, J., Taylor, J., Pratt, M., Mathias, T., Marks, J., Zug, K., & Zirwas, M. (2020). Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001-2016. Dermatitis : contact, atopic, occupational, drug, 31 (3). http://dx.doi.org/10.1097/DER.0000000000000583