Document Type
Journal Article
Publication Date
6-2012
Journal
Nature Communications
Volume
Volume 3
Inclusive Pages
Article number 884
Abstract
Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
APA Citation
Noonan, F. P., Zaidi, M. R., Wolnicka-Glubisz, A., Anver, M. R., Bahn, J., Wielgus, A., et al. (2012). Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment. Nature Communications, 3, 884–. doi:10.1038/ncomms1893
Peer Reviewed
1
Open Access
1
Comments
Reproduced with permission of Nature Publishing Group. Nature Communications.