Title

Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase

Document Type

Journal Article

Publication Date

1-10-2003

Journal

The journal of investigative dermatology. Symposium proceedings

Volume

7

Issue

1

DOI

10.1046/j.1523-1747.2002.19634.x

Abstract

The epidermis is a dynamic and continually renewing surface that provides and maintains a life-sustaining interface with the environment. The epidermal keratinocyte, the major cell type of the epidermis, undergoes a complex and carefully choreographed program of differentiation. This process requires a balance between keratinocyte proliferation, differentiation, and apoptosis. This overview will concentrate on cascades that regulate the balance between keratinocyte cell proliferation and survival, and apoptosis and cell differentiation, with a particular emphasis on the role of the mitogen-activated protein kinase cascades. A summary of the literature suggests that extracellular regulated kinases function to promote keratinocyte proliferation and survival, whereas p38 mitogen-activated protein kinase functions to promote differentiation and apoptosis.

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