Longitudinal course and predictors of depressive symptoms in atopic dermatitis
Journal of the American Academy of Dermatology
atopic dermatitis; depression; eczema; emotional; longitudinal; prospective; pruritus; psychology
BACKGROUND: Atopic dermatitis (AD) is associated with eczematous lesions, pruritus, pain, and sleep disturbance, which may negatively impact mental health over time. OBJECTIVE: Determine the predictors and longitudinal course of depressive symptoms in adults with AD. METHODS: A prospective, dermatology practice-based study was performed (n=695). AD signs, symptoms and severity and Patient Health Questionnaire (PHQ)-9 were assessed. RESULTS: At baseline, 454 (65.32%) had minimal, 139 (20.00%) mild, 57 (8.20%) moderate, 27 (3.88%) moderately severe, and 8 (2.59%) had severe depression. Most had fluctuating levels of depressive symptoms. Feeling bad, thoughts of self-harm, difficulty concentrating, and slow movement were most persistent. Predictors of persistent depression included older age, non-white race, male sex, public or no insurance, more severe itch, skin pain, facial erythema, nipple eczema, sleep disturbance, and presence of pityriasis alba. LIMITATIONS: Single center study. CONCLUSION: Depressive symptoms are closely related to and fluctuate with AD severity over time. Improved control of AD signs and symptoms, particularly itch, may secondarily improve mental health.
Chatrath, Sheena; Lei, Donald; Yousaf, Muhammad; Chavda, Rajeev; Gabriel, Sylvie; and Silverberg, Jonathan I., "Longitudinal course and predictors of depressive symptoms in atopic dermatitis" (2022). GW Authored Works. Paper 981.