Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis

Authors

Maryam Mehdipour Dalivand, The George Washington University, Department of Pathology, Washington, DC, USA.
Parastou Tizro, The George Washington University, Department of Pathology, Washington, DC, USA.
Julie Partain, Oregon Health and Science University, Portland, OR, USA.
Anita Aggarwal, The George Washington University, Department of Medicine, Hematology and Oncology, Washington, DC, USA.
Jack Lichy, The George Washington University, Department of Pathology, Washington, DC, USA.
Francisco Mot Ara, Hospital J.M. de Los Rios, Department of Pathology, Caracas, Venezuela.
Victor E. Nava, The George Washington University, Department of Pathology, Washington, DC, USA.

Document Type

Journal Article

Publication Date

1-1-2022

Journal

Case reports in hematology

Volume

2022

DOI

10.1155/2022/1132544

Abstract

Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.

APA Citation

Mehdipour Dalivand, Maryam; Tizro, Parastou; Partain, Julie; Aggarwal, Anita; Lichy, Jack; Mot Ara, Francisco; and Nava, Victor E., "Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis" (2022). GW Authored Works. Paper 762.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/762

Department

Medicine