ILAE neuroimaging task force highlight: MRI detection of early life epilepsy caused by focal cortical dysplasia

Nathan T. Cohen, Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.
L Gilbert Vezina, Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.
Chima Oluigbo, Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.
Tayyba Anwar, Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.
John Archer, Department of Neurology, Austin Health, the University of Melbourne, Parkville, Melbourne, Australia.
Boris C. Bernhardt, Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Qubec, Canada.
Lorenzo Caciagli, Department of Neurology, Inselspital, Sleep-Wake-Epilepsy-Center, Bern University Hospital, University of Bern, Bern, Switzerland.
Fernando Cendes, Department of Neurology, University of Campinas - UNICAMP, Campinas, Brazil.
Yotin Chinvarun, Epilepsy Center, Neurology Unit, Phramongkutklao Hospital, Bangkok, Thailand.
Luis Concha, Institute of Neurobiology, Universidad Nacional Autónoma de México, Mexico, Mexico.
Paolo Federico, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Eliane Kobayashi, Department of Neurology, University of Texas Southwestern Medical Center and Peter O'Donnell Jr. Brain Institute, Dallas, Texas, USA.
Godwin Ogbole, Department of Radiology, University of Ibadan, Ibadan, Nigeria.
Stefan Rampp, Department of Neurosurgery and Department of Neuroradiology, University Hospital Erlangen, Erlangen, Germany.
Anna Elisabetta Vaudano, Neurophysiology Unit and Epilepsy Center, AOU, Modena, Italy.
Z Irene Wang, Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Shuang Wang, Department of Neurology and Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Gavin P. Winston, Department of Medicine, Queen's University, Kingston, Ontario, Canada.
William D. Gaillard, Center for Neuroscience Research, Children's National Hospital, the George Washington University School of Medicine, Washington, DC, USA.

Document Type

Journal Article

Publication Date

5-3-2025

Journal

Epileptic disorders : international epilepsy journal with videotape

DOI

10.1002/epd2.70038

Keywords

ASL; arterial spin labeling; drug‐resistant epilepsy; focal cortical dysplasia

Abstract

The ILAE Neuroimaging Task Force aims to publish educational case reports that highlight basic aspects of neuroimaging in epilepsy consistent with the ILAE's educational mission. Here, we describe a case series of three neonates with focal cortical dysplasia (FCD)-related drug-resistant epilepsy who underwent surgical intervention. The purpose of this series is to demonstrate the difficulties of identifying FCD in this age group and to highlight the potential added value of arterial spin labeling MRI for delineation of the epileptogenic zone. This series also supports the importance of the 2019 ILAE recommendations for structural imaging in epilepsy, the 2009 ILAE recommendations on imaging infants and children with recent-onset epilepsy, and the 2022 ILAE consensus classification of FCD.

Department

Radiology

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